Effect of candesartan on chronic restraint stress-induced depression-like behaviors in rats
Online published: 2016-05-26
Supported by
Foundation of Shanghai Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine
Objective To observe the effect of candesartan on improving chronic restraint stress (CRS)-induced depression-like behaviors in rats and explore novel targets for the treatment of depression. Methods Twenty-four male Wistar rats were randomly assigned to control group (n=8), stressed group (n=8), and candesartan group (n=8), respectively. Open field test (OFT), sucrose preference test (SPT), and forced swimming test (FST) were performed to evaluate depression-like behaviors in rats. ELISA was used to detect adrenocorticotropin hormone (ACTH) and aniotensin Ⅱ (AngⅡ) levels. Results Compared with the stressed group, rearing frequency and horizontal moving distance in OFT in the candesartan group significantly increased (P=0.000), sucrose preference percentage in SPT elevated (P=0.027), immobility time in FST reduced (P=0.000), and plasma ACTH level significantly decreased (P=0.000). Conclusion Candesartan can improve CRS-induced depression-like behaviors in rats.
Key words: candesartan; chronic restraint stress; depression
CAO Shuang , DU Qin , LI Bing , YUAN Li-fen , DING Jian-wei . Effect of candesartan on chronic restraint stress-induced depression-like behaviors in rats[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2016 , 36(4) : 507 . DOI: 10.3969/j.issn.1674-8115.2016.04.009
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