Objective To investigate changes in the number of ventricular premature contractions in pregnant woman without organic heart disease during gestation period and the impact on fetuses. Methods Clinical data of 140 pregnant women who had delivered from Jan. 2012 to Jun. 2015 and had undergone ambulatory electrocardiogram were enrolled. The changes in ventricular premature contractions in different gestational weeks were retrospectively analyzed and outcomes of mothers and babies were tracked. Results The numbers of ventricular premature contractions increased or decreased after 32 weeks’ gestation as compared with before 28 weeks’ gestation. Changes in the increase and decrease were statistically significant (P=0.004, P=0.001). The differences in delivery weeks, Apgar score, and birth weights between pregnant women with increased and decreased numbers of ventricular premature contractions were not statistically significant. Conclusion The ventricular premature contractions may occur at any phase of gestation and do not necessarily increase with gestational weeks. For pregnant women with ventricular premature contractions and without organic heart disease, gestational outcomes are favorable.