
Research advances in the roles of ncRNAs in polycystic ovary syndrome
Online published: 2016-07-25
Supported by
The National Key Technology R&D Program, 2012BAI32B00; National Natural Science Foundation of China, 81450038
Polycystic ovary syndrome (PCOS) is a common reproductive system disease affecting approximately 5% to 10% of women of childbearing age. The pathogenesis of PCOS remains unclear despite increasing studies in recent years. ncRNAs are RNAs not translating into proteins and mainly involve in many important functions such as regulation of gene expression and epigenetics. ncRNAs become a research hotspot recently. Previous studies have found changes in expressions of various ncRNAs in serum, follicle fluid, and granulosa cells of PCOS patients. It may be a new target for the diagnose of PCOS and provide new idea for studying the pathogenesis of PCOS. This paper reviews recent research advances in the roles of ncRNA in the occurrence and development of PCOS.
Key words: polycystic ovary syndrome; ncRNA; microRNA; lncRNA
YANG Qian , ZHOU Cheng-liang , PAN Jie-xue , HUANG He-feng . Research advances in the roles of ncRNAs in polycystic ovary syndrome[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2016 , 36(6) : 921 . DOI: 10.3969/j.issn.1674-8115.2016.06.027
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