Inflammation is a part of the host defense system and can protect the host against invading pathogens. However, inflammation can also induce endogenous mediators via Toll-like receptors (TLR)，which can promote the occurrence and development of tumor. Understanding the relationship between TLR2 and gastric carcinoma and the possible mechanisms may provide new methods for the treatment of inflammation-associated gastric carcinoma. This paper reviews the structure and function of TLR2, the relationship between TLR2 and inflammation-associated gastric carcinoma, and possible carcinogenic mechanism.