Journal of Shanghai Jiao Tong University (Medical Science) >

2016 , Vol. 36 >Issue 8: 1242

DOI: https://doi.org/10.3969/j.issn.1674-8115.2016.08.026

Review

An update about role of ovarian cancer-associated fibroblasts

  • BU Shi-xia ,
  • LAI Dong-mei
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  • The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

Online published: 2016-08-31

Supported by

Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support，20152236；Project of Shanghai Municipal Science and Technology Commission，14411961500；National Natural Science Foundation of China，81370678

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Abstract

Epithelial ovarian cancer (EOC) remains the leading cause of gynecological cancer-related death. In the tumor microenvironment, the reciprocal inter-communication between ovarian cancer cells and ovarian cancer-associated fibroblasts (OCAFs) plays an important role in the progression of ovarian cancer. This review discusses the latest research progresses about OCAFs, including their possible origins, their effects on the progression of ovarian cancer, the potential diagnostic and predictive value of OCAFs, and the potential of OCAF-targeted therapy.

Key words： ovarian cancer; tumor microenvironment; cancer-associated fibroblasts

Cite this article

BU Shi-xia , LAI Dong-mei . An update about role of ovarian cancer-associated fibroblasts[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2016 , 36(8) : 1242 . DOI: 10.3969/j.issn.1674-8115.2016.08.026

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