Original article (Clinical research)

Analysis of the efficacy of rosuvastatin calcium for different HRCT phenotypes of COPD

  • ZHOU Xi ,
  • YAN Jun-hai ,
  • ZHAO Chun-liu ,
  • HUANG Zhuo-qiong ,
  • ZHANG Bai-ying
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  • Department of Respiratory Medicine, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China

Online published: 2016-12-29

Supported by

Research Project of Shanghai Health and Family Planning Commission,20134161;Research on the Training Plan of Excellent Young Talents of Health and Family Planning Commission in Huangpu District of Shanghai from 2013 to 2016

Abstract

Objective · To investigate the efficacy of rosuvastatin calcium for different high-resolution CT (HRCT) phenotypes of COPD. Methods · Fifty COPD patients were randomly selected and stratified into 3 types, i.e. A, E, M according to emphysema and bronchial wall thickening using HRCT. Based on conventional treatment, patients received 5 mg/d of rosuvastatin calcium for 2 years. Chest HRCT and type stratification were performed prior to treatment. Plasma IL-6 and IL-8 levels and lung function were measured before and after treatment. Results · There were 10 cases of A type, 17 cases of E type, and 23 cases of M type. Differences in IL-8, IL-6, FVC, and FEV1 before and after treatment between 3 types of patients were statistically significant (P < 0.05). Univariate variance analysis showed that differences in the decrease of IL-6 and IL-8 were statistically significant (P = 0.035, P = 0.006), which in A type patients decreased most. The differences in the decrease of FVC and FEV1 were not statistically significant (P=0.154, P = 0.453). Conclusion · Rosuvastatin calcium had efficacy for systemic inflammatory response in COPD patients with different HRCT phenotypes, but was unable to improve pulmonary function. The efficacy for different phenotypes varied.

Cite this article

ZHOU Xi , YAN Jun-hai , ZHAO Chun-liu , HUANG Zhuo-qiong , ZHANG Bai-ying . Analysis of the efficacy of rosuvastatin calcium for different HRCT phenotypes of COPD[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2016 , 36(12) : 1759 . DOI: 10.3969/j.issn.1674-8115.2016.12.016

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