Original article (Clinical research)

Comparative study of clinical features between different subtype bipolar patients with first mania episode

  • ZHOU Ru-bai ,
  • HONG Wu ,
  • ZHAO Guo-qing ,
  • HUANG Jia ,
  • SU You-song ,
  • WANG Yong ,
  • HU Ying-yan ,
  • CAO Lan ,
  • YUAN Cheng-mei ,
  • PENG Dai-hui ,
  • WU Zhi-guo ,
  • WANG Zuo-wei ,
  • XING Meng-juan ,
  • CHEN Jun ,
  • FANG Yi-ru
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  • 1.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2.Shanghai Hongkou District Mental Health Centre, Shanghai 200083, China

Online published: 2017-05-04

Supported by

National Natural Science Foundation of China, 91232719, 81201056, 81301159; Shanghai Health Bureau Excellent Young Talents Program, XYQ2011014; Shanghai Committee of Science and Technology, 12401906200; National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH, 2011-873; National Key Technology Research & Development Program of the Ministry of Science and Technology of China in the “12th Five-year Plan”, 2012BAI01B04

Abstract

 Objective · To compare the clinical features between different subtype bipolar patients with first mania episode, and to contribute to early identification of bipolar disorder. Methods · This study was based on the database named as National Bipolar Mania Pathway Survey (BIPAS). From November 2012 to January 2013, bipolar patients from 26 mental health facilities in China were enrolled in current study. The clinical features were compared between mania patients of different subtypes, including hypomania (group Ⅰ), mania without psychotic symptoms (group Ⅱ), mania with psychotic symptoms (group Ⅲ ) and mixed state (group Ⅳ ). Results · There was significant difference in the percentage of clinical symptoms between different subtype bipolar patients with first mania episode, especially the mania and anxiety related symptoms. Group Ⅰ , Ⅲ , Ⅳ were further compared with group Ⅱ , which was considered as the typical bipolar disorder. The results showed that the mania related symptoms was significantly higher in group Ⅱ , but anxiety related symptoms was significantly higher in group Ⅰ , Ⅲ , Ⅳ . Moreover, Logistic regression analysis revealed that more eloquent or humor and unusually restless could be in favor of the diagnosis of hypomania; younger and mania or hypomania as first episode might be in favor of the diagnosis of mania with psychotic symptoms; older, national minorities and unusually restless could be in favor of the diagnosis of mixed state. Conclusion · The clinical features between different subtype bipolar patients with first mania episode are various, and analysis of the clinical features can contribute to early identification of bipolar disorder.

Cite this article

ZHOU Ru-bai , HONG Wu , ZHAO Guo-qing , HUANG Jia , SU You-song , WANG Yong , HU Ying-yan , CAO Lan , YUAN Cheng-mei , PENG Dai-hui , WU Zhi-guo , WANG Zuo-wei , XING Meng-juan , CHEN Jun , FANG Yi-ru . Comparative study of clinical features between different subtype bipolar patients with first mania episode[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2017 , 37(4) : 490 . DOI: 10.3969/j.issn.1674-8115.2017.04.013

Outlines

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