Objective · To analyze clinical and pathological characteristics of gastric malignancies from a single center of Ruijin Hospital, and provide references for making healthy policy on gastric tumors.  Methods · The data sources were from hospital in-patients database including demographic information, family history, clinicopathological information, and census registering information during 2005 to 2014. The demographic data and clinicopathological data were analyzed.  Results · The total number was 3 315 cases with gastric malignancies (2 184 male patients and 1 131 female patients). It was about 2 times as high in males as in females. The patient age was between 18 to 98 years old (mean 59.71 years old). Based on pathologic diagnosis, 3 122 cases (94.2%) were gastric adenocarcinoma, others were gastrointestinal stromal tumors (5.5%), neuroendocrine tumor (0.2%) and malignant lymphoma (0.1%). Out of patients with gastric carcinoma, about 4.46% of cases ran in families.  Conclusion · Over 94% cases of gastric malignancies are gastric carcinomas. Specific risk profiles of gastric carcinomas include age, gender and family factors.