Journal of Shanghai Jiao Tong University (Medical Science) >

2018 , Vol. 38 >Issue 4: 426

DOI: https://doi.org/10.3969/j.issn.1674-8115.2018.04.013

Original article (Clinical research)

Value of hypoxia-inducible factor 1α in diagnosis and prognosis of acute decompensated chronic heart failure

  • SUN Ke-yuan1 ,
  • HUANG Gao-zhong1 ,
  • YUAN Fang2 ,
  • CHEN Shi-hong3 ,
  • FU Guo-xiang1
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  • 1. Department of Geriatrics, Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai 200233, China; 2. Department of Emergency, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China; 3. Department of Clinical Laboratory, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China

Online published: 2018-05-03

Supported by

Special Medical Fund for Acute Heart Failure in Changning District, Shanghai, 20162002

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Abstract

Objective · To investigate the value of hypoxia-inducible factor 1α (HIF-1α) in diagnosis and prognosis of acute decompensated chronic heart failure (CHF). Methods · 32 patients with acute decompensated CHF (Group A), 33 patients with sCHF (Group B) and 30 controls (Group C) were included. HIF-1α, B-type natriuretic peptide (BNP) and other biochemical indicators in blood were detected. Length of stay and readmission frequency within 3 months of Group A were recorded. Correlations between HIF-1α and other indicators were analyzed. ROC curves of HIF-1α and BNP were developed to compare their diagnostic values. Results · The HIF-1α and BNP levels of Group A were both significantly higher than those of Group B and Group C (P<0.05). HIF-1α was positively correlated with serum creatinine, hemoglobin, BNP, length of stay and readmission frequency within 3 months(P<0.05). Areas under curves of HIF-1α and BNP showed no statistically difference (P>0.05). Conclusion · HIF-1α has a certain value in diagnosis and prognosis of acute decompensated CHF.

Key words： hypoxia-inducible factor 1&; alpha; acute decompensated chronic heart failure; type B natriuretic peptide; diagnosis; prognosis

Cite this article

SUN Ke-yuan1 , HUANG Gao-zhong1 , YUAN Fang2 , CHEN Shi-hong3 , FU Guo-xiang1 . Value of hypoxia-inducible factor 1&alpha; in diagnosis and prognosis of acute decompensated chronic heart failure[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2018 , 38(4) : 426 . DOI: 10.3969/j.issn.1674-8115.2018.04.013

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