Various forms of noninvasive respiratory support have been applied to the treatment of infant respiratory distress and hypoxemia. The most common noninvasive respiratory support in neonatal intensive care unit is nasal continuous positive airway pressure (NCPAP). But the NCPAP systems are not always well acceptedthe neonatal population, with the risk of mucosal injury and nosocomial infection. In recent years, humidified high-flow nasal cannula (HHFNC) has been introduced and developed as a possible alternative to NCPAP for noninvasive respiratory support mode, becait increases patients’ comfort and the effectiveness of the ventilation. This article summarized the current research progress of HHFNC therapy in pediatric patients.