Journal of Shanghai Jiao Tong University (Medical Science) >

2018 , Vol. 38 >Issue 7: 719

DOI: https://doi.org/10.3969/j.issn.1674-8115.2018.07.001

Review for outstanding international article

Ubiquitin-like modification (SUMOylation) and genomic stability

  • CHENG Jin-ke
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  • Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University College of Basic Medical Sciences; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai 200025, China

Online published: 2018-07-30

Supported by

National Natural Science Foundation of China，81430069，81721004

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Abstract

The mechanism of protein post-translational modifications in regulation of cell mitosis and genomic stability is always a hot issue in biological researches. The present review introduced the functional activity of de-SUMOylase SENP3 in sister chromatin dissociation at mitosis, and demonstrated a new molecular mechanism of cross-talk regulation between protein SUMOylation and phosphorylation in maintaining genomic stability.

Key words： SUMOylation; phosphorylation; SENP3

Cite this article

CHENG Jin-ke . Ubiquitin-like modification (SUMOylation) and genomic stability[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2018 , 38(7) : 719 . DOI: 10.3969/j.issn.1674-8115.2018.07.001

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