Objective · To examine quality of life and its influencing factors in patients over 12 months after diagnosis of non-small cell lung cancer (NSCLC). Methods · A total of 111 patients included in the study completed the self-reported measures. Quality of life was measured using Functional Assessment of Cancer Therapy–Lung. Other measures included socio-demographic characteristics, disease- and treatment-related information, and emotional feelings. Results · The factors influencing the quality of life of NSCLC patients were investigated two approaches: treatment and subjective feeling. Univariate Logistic regression analysis found the risk factors for low quality of life included sense of low self-esteem and loneliness, bone metastasis, pathological type, chemotherapy cycle, age, cohabitant type and financial burden. Conclusion · The factors associated with quality of life in lung cancer patients are diverse and extensive, and it warrants attention on psychological support and symptom management for these patients.