Review

Progress in 5-HT2C receptor as a therapeutic target for treatment of schizophrenia

  • WANG Ye-wei ,
  • ZHANG Chen
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  • Biochemical Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

Online published: 2018-07-30

Supported by

National Natural Science Foundation of China, 81000581, 81471358, 81771450; National Key Clinical Discipline at Shanghai Mental Health Center, OMA-MH 2011-873; Shanghai Science and Technology Development Fund, 12140904200; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20152530)。

Abstract

With an increasing number of reports on side effects including antipsychotic induced weight gain and cardiovascular risks, interest of the researchers has been transferred to a new target for the treatment of schizophrenia—serotonin 2C receptor (5-HT2C receptor). On one hand, activation on 5-HT2C receptors can lead to decrease of dopamine in the nigrostriatum, which presents its potential antipsychotic effect; on the other hand, the second-generation of antipsychotics’ antagonism on the 5-HT2C receptors is an important factor of patients weight gain. Conversely, agonism on the 5-HT2C receptors may result in weight loss efficacy. This paper introduced the potential therapeutical effect of 5-HT2C receptor on schizophrenia and the relation between the receptor and correlated weight gain.

Cite this article

WANG Ye-wei , ZHANG Chen . Progress in 5-HT2C receptor as a therapeutic target for treatment of schizophrenia[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2018 , 38(7) : 801 . DOI: 10.3969/j.issn.1674-8115.2018.07.016

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