Objective · To evaluate the reliability and validity of the Chinese version of the endometriosis health profile-5 (EHP-5) and to evaluate whether patients with different syndromes can be well discriminated with EHP-5. Methods · A total of 102 patients with pathologically proven endometriosis completed the questionnaire. The reliability and internal consistency of the Chinese version of EHP-5 were assessedCronbachs α coefficient. Creteria validity of the Chinese version of EHP-5 was investigatedcomparing it with the EuroQol five-dimension questionnaire (EQ-5D). The patients were further subdivided into two subgroups according to the symptom of dysmenorrhea, dysmenorrhea, menstrual disorder or infertility. The scores in the five items of core questionnaire were compared between asymptomatic and symptomatic patients using Mann-Whitney U test. Results · The Cronbachs α coefficient was 0.877 for five items the core questionnaire, and 0.843 for six items the modular questionnaire. The internal consistency also showed satisfactory result (Cronbachs α >0.7). The correlations of related subscale scores between EHP-5 and EQ-5D were significant in some dimensions. There was significant differences in scores between asymptomatic and symptomatic subgroups dividedthe symptom of dysmenorrhea or dyspareunia. But no significant difference was founds in scores between asymptomatic and symptomatic subgroups dividedthe symptom of menstrual disorders or infertility. Conclusion · The Chinese version of EHP-5 is an acceptable, reliable and valid measure of quality of life in endometriosis patients with the symptom of dysmenorrhea or dysmenorrhea. However, EHP-5 could not well discriminate endometriosis patients with the symptom of menstrual disorder or infertility. More specific items are necessary so as to make EHP-5 an intervention tool for the prognosis and follow-up of patients with different symptoms.