Objective · To investigate condom among unmarried female miworkers in Shanghai and explore its relation with some psychosocial problems. Methods · A questionnaire survey was conductedcluster random sampling. A total of 903 unmarried female miworkers who had sexual experience were enrolled to evaluate their condom and psychosocial factors. Logistic regression was used to analyze the related factors of condom use. Results · Among the unmarried female miworkers, the percentage of consistent condom was only 13.8%. Univariate Logistic regression showed that low self-esteem (OR0.47, 95% CI0.25-0.90) and depression (OR0.59, 95% CI0.38-0.93) were related to inconsistent condom after correcting demographic factors. Multivariate Logistic regression showed that depression (OR0.58, 95% CI0.37-0.90) was the main factor related to inconsistent condom use. The participants with at least two psychosocial problems were more difficult to condoms consistently (OR0.56, 95% CI0.32-0.97). Conclusion · The unmarried female miworkers with depression or co-occurring psychological problems in Shanghai are more likely to have unsafe sex behavior, which indicates the importance of psychological interventions.