Objective · To evaluate the outcomes of patients with acute proximal deep vein thrombosis (DVT) and iliofemoral stenosis who underwent stenting after AngioJet rheolytic thrombectomy. Methods · A retrospective analysis was conducted on the patients who received iliofemoral vein stent implantation after the treatment of iliofemoral vein DVT with AngioJet thrombectomy January 2015 to December 2016 in the Vascular Surgery Department of Shanghai Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine. The outcomes included technical success rate, patency rate at 1 year and incidence rate of post thrombotic syndrome (PTS). The effect of direct stenting after AngioJet rheolytic thrombectomy was compared with that of staged stenting. Results · A total of 97 patients were enrolled and divided into direct stenting group (n50) and staged stenting group (n47). The technical success rates were 100% in both groups, and there was no 30-day mortality and serious complication. Immediate clinical improvement in direct group was significantly higher than that in staged group (92.0% vs 68.1%, P0.000). The primary patency rates at 1 year were 93.6% in the direct group and 97.8% in the staged group (P0.323). The Villalta scores in the direct group were significantly higher than those in the staged group (4.21±2.37 vs 2.11±1.82, P0.000). Conclusion · Both direct and staged stenting are effective treatment modalities for patients with acute proximal DVT. The decision of the stenting timing should be based on individual case.