Objective · To study the effect of the number of thrombectomy on the prognosis of patients with acute ischemic stroke treated with mechanical thrombectomy (MT). Methods · Retrospective analysis was performed in 88 acute ischemic stroke patients treated with MT in Shanghai Ninth Peoples Hospital March 2013 to April 2018. Based on the number of thrombectomy, all the patients were divided into the group with lower number of thrombectomy (group A) ( ≤ 2 times of thrombectomy) and the group with higher number of thrombectomy (group B) (>2 times of thrombectomy). Revascularization rate, incidence of intracerebral hemorrhage, score of National Institute of Health Stroke Scale (NIHSS) and mortality at 7 d after surgery, modified Rankin score (mRs) and mortality at 90 d after surgery were compared between the two groups. Results · Compared with group B, there were no statistically significant differences in the incidence of intracerebral hemorrhage, and rates of symptom improvement at 7 d and good prognosis at 90 d in group A (all P>0.05). But the mortality at 7 d and 90 d in group A was lower than that in group B (P0.003, P0.031), and the rate of successful revascularization in group A was significantly higher than that in group B (P0.010). Conclusion · Multiple thrombectomy is not significantly correlated with intracerebral hemorrhage, early symptom improvement and good prognosis at 90 d, but it is correlated with the rates of revascularization and mortality.