Objective · To introduce a standardized workflow for clinical application of Chinese customized TC4/UHMWPE connected total temporomandibular joint (TMJ) prostheses, and to evaluate its accuracy and clinical effectiveness. Methods · Eight patients with the end stage TMJ diseases were included in this study. The computed tomography (CT) data for patients were obtained and transformed into the Mimics 18.0 software preoperatively for the designing of the prostheses and digital templates. Three-dimensional (3D) printing, friction spot welding (FSW) and computer-aided manufacture (CAM) were used to fabricate different components of the prostheses. The effectiveness of intraoperative application and the accuracy of merging results were evaluated postoperatively. Results · With the guidance of digital templates and virtual surgical planning (VSP), all the prostheses were placed smoothly and fixed stably during surgical procedures. The merging results showed that the prostheses position matched with the preoperative design well, with an mean deviation of 0.417 mm (range: 0.279 to 0.561 mm) for the whole prosthesis system. All the patients exhibited good facial symmetry and satisfactory improvement in pain, function and mouth opening postoperatively. Conclusion · The standardized workflow ensures the accuracy and efficiency in clinical application of Chinese customized total TMJ prostheses.