Objective · To explore the incidence and risk factors of infection related to totally implanaccess port (TIAP) in upper arm in cancer patients. Methods · A total of 1 961 patients who received TIAP for deliverance of chemotherapy at Renji Hospital, Shanghai Jiao Tong University School of Medicine during the period February 2014 to December 2018. The general clinical data, catheterization status, bacteriological data and incidence of TIAP-related infections were retrospectively analyzed. The univariate analysis and multivariate Logistic regression analysis were used to determine the risk factors TIAP-related infections. Results · A total of 43 patients developed TIAP-related infections, with an incidence of 2.2% (43/1 961). The mean time interval the implantation of upper arm TIAP to the diagnosis of infection was (116.88±95.39) d (7-377 d). In univariate analysis, gender (P0.001), catheter diameter (P0.000), upper extremity venous thrombosis (UEVT) (P0.000) and outpatient (P0.005) were significantly associated with the risk of infection related to upper arm TIAP. Multivariate binary Logistic regression analysis showed that gender (OR0.35, P0.012), UEVT (OR31.59, P0.000) and catheter diameter (OR2.81, P0.005) were three significant independent predictors of infection related to upper arm TIAP. Conclusion · Gender, UEVT and catheter diameter are independent risk factors for upper arm TIAP-related infection.