Journal of Shanghai Jiao Tong University (Medical Science) >

2019 , Vol. 39 >Issue 11: 1325

DOI: https://doi.org/10.3969/j.issn.1674-8115.2019.11.018

Review

Advances in the study of T cell immunity in invasive fungal infections secondary to sepsis

  • ZHAO Yi-si1 ,
  • YU Ying-xi1 ,
  • LIN Shi-hui2 ,
  • XU Fang1 ,
  • 2
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  • 1. Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; 2.Department of Pathophysiology, The Basic Medicine of Chongqing Medical University, Chongqing 400016, China

Online published: 2019-12-16

Supported by

National Natural Science Foundation of China, 81873928, 81801894, 81570069

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Abstract

Invasive fungal infections (IFI) has high morbidity and mortality. It is more common in hospital infections, and especially in sepsis, the risk of secondary IFI is increased. Immunosuppression of sepsis may affect immune function of T cells, and various T cells subsets have different effects on various fungal pathogens of IFI. The review discusses the pathophysiological processes, mechanism and therapeutic methods of T cell immunity in IFI secondary to sepsis, into summarize the role of T cells in IFI secondary to sepsis and introduce the new immunotherapy.

Key words： invasive fungal infections; T-cell subsets; sepsis; immunotherapy

Cite this article

ZHAO Yi-si1 , YU Ying-xi1 , LIN Shi-hui2 , XU Fang1 , 2 . Advances in the study of T cell immunity in invasive fungal infections secondary to sepsis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2019 , 39(11) : 1325 . DOI: 10.3969/j.issn.1674-8115.2019.11.018

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