Journal of Shanghai Jiao Tong University (Medical Science) >

2020 , Vol. 40 >Issue 1: 51

DOI: https://doi.org/10.3969/j.issn.1674-8115.2020.01.008

Original article (Clinical research)

Sleep apnea hypopnea syndrome prolongs rapid eyes movement sleep time in depressive state and shortens deep sleep time in manic state in patients with bipolar disorder

  • JIN Zhi-xing ,
  • WANG Mei-ti ,
  • ZHOU Qian ,
  • Lü Dong-bin ,
  • WANG Fan ,
  • HUANG Qin-te ,
  • WU Zheng-lin ,
  • LI Hai-bin ,
  • XU Chu-chen ,
  • CAO Lan ,
  • ZHAO Jie ,
  • CAO Tong-dan ,
  • HUANG Hai-jing ,
  • FANG Yi-ru ,
  • HONG Wu
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  • 1. Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Department of Psychiatry, Shanghai Huangpu District Center for Mental Health, Shanghai 200023, China

Online published: 2020-03-05

Supported by

National Key R&D Program of China (2016YFC0906300); National Natural Science Foundation of China (81701344); Scientific Research Project of Shanghai Municipal Commission of Health and Family Planning (201740115).

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Abstract

Objective · To observe the effect of sleep apnea hypopnea syndrome (SAS) on sleep staging of bipolar disorder patients in different states. Methods · A total of 210 healthy controls aged 18–65 and 235 bipolar disorder patients of the same age were collected. The bipolar disorder patients were divided into depressive, manic and mixed states. Sleep time structure, sleep posture, heart rate and other indicators were collected by using sleep quality assessment system based on cardiopulmonary coupling analysis. According to whether the apnea-hypopnea index (AHI) was ≥ 5 times/h, whether they had SAS were determined. Two-way multivariate analysis of variance was conducted, investigating the effect of clinical states and SAS, on several sleep indicators. Results · SAS significantly prolonged rapid eyes movement (REM) sleep time of patients in depressive state (P=0.000) and shortened deep sleep time of patients in manic state (P=0.011). In addition, the heart rate during sleep (including deep sleep, light sleep and REM sleep) of patients in manic state increased most significantly among the three clinical states (P=0.000). Lying supine aggravated SAS most significantly in manic state among the three clinical states (P=0.002). Conclusion · SAS has different effects on the sleep staging of bipolar disorder patients in different states.

Key words： bipolar disorder; manic state; depressive state; mixed state; sleep apnea hypopnea syndrome

Cite this article

JIN Zhi-xing , WANG Mei-ti , ZHOU Qian , Lü Dong-bin , WANG Fan , HUANG Qin-te , WU Zheng-lin , LI Hai-bin , XU Chu-chen , CAO Lan , ZHAO Jie , CAO Tong-dan , HUANG Hai-jing , FANG Yi-ru , HONG Wu . Sleep apnea hypopnea syndrome prolongs rapid eyes movement sleep time in depressive state and shortens deep sleep time in manic state in patients with bipolar disorder[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2020 , 40(1) : 51 . DOI: 10.3969/j.issn.1674-8115.2020.01.008

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