Journal of Shanghai Jiao Tong University (Medical Science) >

2020 , Vol. 40 >Issue 1: 134

DOI: https://doi.org/10.3969/j.issn.1674-8115.2020.01.022

Review

Recent advances in using of stem cell-derived extracellular vesicles in treating central nervous system diseases

  • HE Zheng-hui ,
  • WANG Yang ,
  • DENG Zhi-feng
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  • 1. School of Clinical Medicine, Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai 200233, China; 2.Institute of Microsurgery on Extremities, Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai 200233, China; 3. Department of Neurosurgery, Shanghai Sixth Peoples Hospital Shanghai Jiao Tong University, Shanghai 200233, China

Online published: 2020-03-05

Supported by

National Natural Science Foundation of China (81671209).

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Abstract

Stem cell-derived extracellular vesicles can regulate functions of targeting cells in lesions and have fewer risks in treating diseases. In central nervous injury lesions, stem cell-derived extracellular vesicles can promote neurogenesis and angiogenesis and regulate nervous inflammation, which promotes the recovery of the nerve injury. Stem cell-derived extracellular vesicles can ease Aβ protein-related neuron damage in Alzheimers disease. Stem cell-derived extracellular vesicles also can deliver microRNA and chemotherapeutic agents to neuroglioma cells. This review introduces recent advances in using stem cell-derived extracellular vesicles in treating central nervous system diseases.

Key words： stem cell-derived extracellular vesicles (SC-EVs); central nervous system injury; Alzheimer’s disease; neuroglioma

Cite this article

HE Zheng-hui , WANG Yang , DENG Zhi-feng . Recent advances in using of stem cell-derived extracellular vesicles in treating central nervous system diseases[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2020 , 40(1) : 134 . DOI: 10.3969/j.issn.1674-8115.2020.01.022

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