Objective · To evaluate nasolabial soft tissue changes of Chinese patients with malocclusion after maxillary anterior movement by Le FortⅠosteotomy with three-dimensional measurement. Methods · From Jan. to Dec. 2017, 37 patients with skeletal Class Ⅲ malocclusion from Department of Oral and Craniomaxillofacial Surgery of Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, who underwent maxillary Le FortⅠosteotomy for anterior movement and bilateral sagittal split ramus osteotomy (bi-maxillary orthognathic surgery), were included. A full cranial spiral CT scan and three-dimensional facial soft tissue images were performed within 1 week before and 6 months after operation. Landmarks, relative distance and angle of nasolabial soft tissue were located and measured by 3dMD vultus software, and the differences before and after operation were compared. Results · After bi-maxillary orthognathic surgery, the alar width increased by an average of 0.82 mm, the subalar width increased by an average of 1.07 mm, the upper lip length increased by an average of 1.41 mm, the nasolabial angle increased by an average of 3.09?, and the pronasal angle decreased by an average of 1.51?(all P<0.05), while nasal height, nasal length and nasal frontal angle were basically stable. Conclusion · After the maxillary Le Fort I osteotomy for anterior movement, the face of patient with malocclusion is improved, and the nasolabial soft tissue is also changed.