Objective · To investigate the expression of long noncoding RNA （lncRNA） COL11A1-208 in oral squamous cell carcinoma （OSCC）, and evaluate its potential value in prognosis prediction and diagnosis of OSCC. Methods · The differentially expressed lncRNAs from six pairs of OSCC tissues and the para-carcinoma tissues were detected by lncRNA microarray. Quantitative real-time PCR （qPCR） was used to detect the expression of COL11A1-208 in seventy-four pairs of OSCC tissues and para-carcinoma tissues. The difference of COL11A1-208 expression among the patients with different clinical features were analyzed. The potential effectiveness of COL11A1-208 level in the diagnosis of OSCC was evaluated by the receiver operating characteristic （ROC） curve. Kaplan-Meier survival analysis was used to analyze the effects of COL11A1-208 on the 3-year overall survival rate of OSCC patients. Results · Compared with the para-carcinoma tissues, COL11A1-208 was highly expressed in OSCC tissues （P=0.000）, which was consistent with the results of lncRNA microarray. The expression of COL11A1-208 in the patients with advanced TNM stage （Ⅲ - Ⅳ） was significantly higher than that with TNM stage Ⅰ - Ⅱ （P=0.001）. The area under ROC curve of COL11A1-208 as a biomarker for the diagnosis of OSCC was 0.702 （95%CI 0.617 -0.788, P=0.000）, and the sensitivity and specificity were 87.8% and 54.1%, respectively. The 3-year overall survival rate of the patients with low expression of COL11A1-208 was significantly longer than that of the patients with high expression （P=0.002）. Conclusion · The expression of COL11A1-208 is up-regulated in OSCC tissues, which is even higher in the patients with advanced TNM stage. COL11A1-208 might have potential value in prognostic prediction and diagnosis of OSCC.