Objective · To analyze the influencing factors of frailty syndrome in elderly patients with stable coronary artery disease (SCAD). Methods · A total of 101 SCAD patients (aged≥60 years) hospitalized in the Department of Geriatrics and Cardiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine from March to September, 2019, were selected. The comprehensive geriatric assessment was used to evaluate the health status and complications of the patients. According to patients’ frailty status evaluated by the Fried frailty phenotype, the patients were divided into frailty group and non-frailty group. Multivariate Logistic regression model was used to analyze the influencing factors of frailty syndrome in elderly patients with SCAD. Results · Among 101 elderly patients with coronary heart disease, 53 cases were complicated with frailty syndrome. There were statistically significant differences in age, Charlson comorbidity index (CCI), the proportion of sleep disorders, falls in the past year, history of multiple drug use, grip strength, Gensini score, cystatin level, brain natriuretic peptide (BNP) and serum creatinine (Scr) levels between the two groups (all P<0.05). Multivariate Logistic regression analysis showed that Gensini score (β=0.027, SE=0.012, P=0.028) and grip strength (β=-0.076, SE=0.030, P=0.012) were the influencing factors of elderly SCAD patients complicated with frailty syndrome. Conclusion · Elderly patients with SCAD are prone to be complicated with frailty syndrome. The Gensini score and grip strength measurement will help clinicians identify and intervene in frailty syndrome early.