As a non-invasive neuromodulation technique, transcranial focused ultrasound stimulation has the advantages of safety, high focused accuracy, deep penetration depth and easy compatibility with the synchronous recording of neuroimaging. Transcranial focused ultrasound stimulation has been used in the treatment of essential tremor, Parkinson's disease, brain tumors, etc. However, the progress in the area of psychiatry is still limited. The current research status of transcranial focused ultrasound stimulation in the treatment of psychiatric disorders is reviewed in this article, including the analysis of difficulties in its application and the prospect for the future direction.