Journal of Shanghai Jiao Tong University (Medical Science) >

2021 , Vol. 41 >Issue 3: 386 - 390

DOI: https://doi.org/10.3969/j.issn.1674-8115.2021.03.018

Review

Progress in researches on improving engraftment of hematopoietic stem/progenitor cells of cord blood

  • Liu-xin NING ,
  • Si-guo HAO
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  • Department of Hematology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China

Received date: 2020-01-15

  Online published: 2021-04-06

Supported by

Three-year Action Plan for Clinical Skills and Clinical Innovation in Municipal Hospitals of Shanghai Shenkang Hospital Development Center(16CR1033B)

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Abstract

Cord blood transplantation (CBT) has been widely used in the treatment of hematologic malignancies and non-malignant hematologic diseases both in children and adults. Compared with other sources of hematopoietic stem/progenitor cell (HSPC) transplantation, CBT has a higher rate of engraftment failure and delayed hematopoietic system and immune system recovery, thereby increasing the mortality caused by infection and other transplant-related complications. Therefore, how to promote the engraftment of cord blood HSPC has been a hot spot in CBT for many years. The article reviews the latest advances in the strategies to improve the engraftment of HSPC of cord blood.

Key words： cord blood transplantation (CBT); hematopoietic stem/progenitor cell (HSPC); in vitro expansion; engraftment; homing

Cite this article

Liu-xin NING , Si-guo HAO . Progress in researches on improving engraftment of hematopoietic stem/progenitor cells of cord blood[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2021 , 41(3) : 386 -390 . DOI: 10.3969/j.issn.1674-8115.2021.03.018

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