Journal of Shanghai Jiao Tong University (Medical Science) >

2023 , Vol. 43 >Issue 3: 365 - 373

DOI: https://doi.org/10.3969/j.issn.1674-8115.2023.03.013

Review

Research progress in ferroptosis regulation in the treatment of liver diseases

  • Chen CHEN ,
  • Zhuoan CHENG ,
  • Cun WANG ,
  • Qiang XIA
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  • 1.Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200120, China
    2.State Key Laboratory of Oncogenes and Related Gens, Shanghai Cancer Institute, Shanghai 200120, China
    3.Shanghai Institute of Transplantation, Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai 200120, China
XIA Qiang, E-mail: xiaqiang@shsmu.edu.cn.

Received date: 2022-07-12

  Accepted date: 2022-12-16

  Online published: 2023-03-28

Supported by

National Natural Science Foundation of China(92059205)

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Abstract

Ferroptosis is a form of cell death that results from accumulation of lipid reactive oxygen species, marked by iron-dependent oxidative damage of phospholipids. Accumulation of iron and lipid hydroperoxides are hallmarks of ferroptosis. Diverse biological contexts, including iron handling, redox homeostasis, imbalance of lipid synthesis, participate in ferroptosis. Mechanistically, pathways of ferroptosis regulation involving System Xc--glutathione (GSH)-glutathione peroxidase 4 (GPX4) axis, coenzyme Q10 (CoQ10)-ferroptosis suppressor protein 1 (FSP1)-ubiquinol axis, GTP cyclohydrolase 1 (GCH1)-tetrahydrobiopterin (BH4)-dihydrofolate reductase (DHFR) axis, dehydrogenase (DHODH)-ubiquinol axis have been discovered. Ferroptosis has been implicated in multiple liver diseases, such as hepatocellular carcinoma, liver ischemia-reperfusion injury, steatohepatitis, liver fibrosis, cirrhosis and liver metabolic diseases. Elucidating its mechanism offers various tractable nodes for therapeutic intervention. Here, we summarize insights into the molecular characteristics, biological processes, regulatory pathways of ferroptosis and its recent advances in the treatment of liver diseases.

Key words： ferroptosis; liver disease; lipid peroxidation

Cite this article

Chen CHEN , Zhuoan CHENG , Cun WANG , Qiang XIA . Research progress in ferroptosis regulation in the treatment of liver diseases[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023 , 43(3) : 365 -373 . DOI: 10.3969/j.issn.1674-8115.2023.03.013

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