Journal of Shanghai Jiao Tong University (Medical Science) >

2023 , Vol. 43 >Issue 5: 606 - 610

DOI: https://doi.org/10.3969/j.issn.1674-8115.2023.05.011

Clinical research

A comparative study of prepulse inhibition in children with first episode schizophrenia and normal children

  • Xiaojun XU ,
  • Minjie YE ,
  • Yuchen WANG ,
  • Wenxia WANG ,
  • Sheng QIAN ,
  • Dandi YE ,
  • Lele PAN ,
  • Xin HU ,
  • Xiaoli YIN ,
  • Meihua LI ,
  • Guangyao LING
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  • 1.Department of Public Health, The Affiliated Kangning Hospital of Wenzhou Medical University; Zhejiang Provincial Clinical Research Center for Mental Disorder, Wenzhou 325007, China
    2.Department of Geriatrics, Jingan District Mental Health Center, Shanghai 200436, China
YE Minjie, E-mail: minjieye@163.com.
WANG Yucheng, E-mail: 284382038@qq.com.

Received date: 2023-01-03

  Accepted date: 2023-02-22

  Online published: 2023-07-11

Supported by

Medical and Health Science and Technology Plan of Zhejiang Province(2023KY306)

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Abstract

Objective ·To explore the characteristics of sensory gating and its variation in children with first episode schizophrenia (COS) by using a new technique of prepulse suppression (PI). Methods ·By using the ERP recording and analysis system of brain products, PI was detected in 56 patients with COS and 38 healthy children (NC) using the paradigm of single strong stimulus and weak stimulus+strong stimulus. The patients′ performance was comprehensively evaluated with Positive and Negative Syndrome Scale (PANSS), Social Disability Screening Schedule (SDSS), Social Adjustment Rating Scale (SSRS), and Family Interview Schedule (FIS). Results ·The social objective support formed by summing up the above scales was compared with the quantitative stanard of social support [the standard of social support scale was (8±2) points, and the value of COS group was (10±3) points], and the difference was statistically significant (P=0.007). No correlation was found between PI and PANSS total score and each factor score (all P>0.05). The latency of startle reflex in the COS group was longer than that in the NC group [the NC group was (86±11) ms, the COS group was (97±13) ms, P=0.001]. In the COS group, the amplitude of startle reflex of weak stimulus+strong stimulus was higher, and the latency was longer than that of the NC group [NC group: (39±12) μV, COS group (47±21) μV, P=0.007; the latency of the normal group was (84±17) ms, and that of the COS group was (97±20) ms, P=0.003]. PI inhibition rate in the COS group was lower than that in the NC group [(66±32) % in the NC group, (43±37) % in the COS group, P=0.000]. Conclusion ·COS patients have the same PI abnormality as adult schizophrenia. The change of PI inhibition may be the result of biological markers reflecting the change of agitated emotion in COS patients.

Key words： schizophrenia; children; prepulse inhibition (PI); biological markers (BM)

Cite this article

Xiaojun XU , Minjie YE , Yuchen WANG , Wenxia WANG , Sheng QIAN , Dandi YE , Lele PAN , Xin HU , Xiaoli YIN , Meihua LI , Guangyao LING . A comparative study of prepulse inhibition in children with first episode schizophrenia and normal children[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023 , 43(5) : 606 -610 . DOI: 10.3969/j.issn.1674-8115.2023.05.011

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