Journal of Shanghai Jiao Tong University (Medical Science) >

2023 , Vol. 43 >Issue 6: 761 - 767

DOI: https://doi.org/10.3969/j.issn.1674-8115.2023.06.013

Review

Research progress in the relationship between mitochondrial dysfunction and osteoporosis

  • Fangquan JIN ,
  • Chenghu FAN ,
  • Xiaodong TANG ,
  • Yantong CHEN ,
  • Bingxian QI
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  • 1.Clinical College of Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730030
    2.Gansu Provincial Hospital of Traditional Chinese Medicine Spine Center, Lanzhou 730050
TANG Xiaodong, Email:1927981689@qq.com.

Received date: 2023-02-08

  Accepted date: 2023-06-21

  Online published: 2023-06-28

Supported by

National Natural Science Foundation of China(81760877);Social Development Project of Key Research and Development Program of Gansu Provincial Department of Science and Technology(21ZD4FA009);Key Project of Traditional Chinese Medicine of Gansu Province(GZKZ-2021-3);Scientific Research Project of Traditional Chinese Medicine of Gansu Province(GZKP-2021-12)

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Abstract

Osteoporosis (OP) is a chronic senile bone disease characterized by decreased bone mass and increased bone fragility. There are many inducing factors and the pathogenesis is complex. To explore the mechanism of OP and improve clinical efficacy has always been a hot topic in life science. In recent years, it has been found that mitochondria play an important role in the pathogenesis of OP. Functional abnormalities such as mitochondrial energy metabolism, mitochondrial oxidative stress, mitochondrial autophagy, mitochondrial-mediated apoptosis and mitochondrial dynamics can interfere with the differentiation of bone marrow mesenchymal stem cells through different signal pathways, cytokines and protein expression to regulate osteoblast activity, proliferation and differentiation, and start the process of osteoclast apoptosis. Therefore, taking mitochondria as the target, regulating the functions of mitochondrial energy metabolism, oxidative stress, autophagy and kinetics, inducing osteogenic differentiation of bone marrow mesenchymal stem cells, promoting osteoblast differentiation and mineralization, and inducing osteoclast apoptosis are potential strategies for the prevention and treatment of OP. In this article, the mechanism of mitochondrial dysfunction in OP was reviewed by referring to relevant literature at home and abroad, in order to lay a foundation for further research.

Key words： mitochondria; osteoporosis; oxidative stress; autophagy; mitochondrial dynamics

Cite this article

Fangquan JIN , Chenghu FAN , Xiaodong TANG , Yantong CHEN , Bingxian QI . Research progress in the relationship between mitochondrial dysfunction and osteoporosis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023 , 43(6) : 761 -767 . DOI: 10.3969/j.issn.1674-8115.2023.06.013

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