Journal of Shanghai Jiao Tong University (Medical Science) >

2024 , Vol. 44 >Issue 3: 373 - 378

DOI: https://doi.org/10.3969/j.issn.1674-8115.2024.03.010

Review

Advances in the study of neurovascular coupling in bone repair

  • Shuhang HE ,
  • Shangchun GUO ,
  • Shicong TAO
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  • 1.Department of Orthopedic Surgery, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
    2.Clinical Medical College of Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
    3.Shanghai Institute of Microsurgery on Extremities, 200233, China
TAO Shicong, E-mail: sctao@shsmu.edu.cn.

Received date: 2023-08-13

  Accepted date: 2024-02-09

  Online published: 2024-03-28

Supported by

National Natural Science Foundation of China(81802226);Shanghai Pujiang Program(2019PJD038);Shanghai "Rising Stars of Medical Talent" Youth Development Program in 2020;"Two-hundred Talents" Program of Shanghai Jiao Tong University School of Medicine(2022-017);Shanghai Sixth People′s Hospital Excellent Young Scientist Development Program(ynyq202101)

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Abstract

Bone repair is a complex physiological process. The nerves within the bone can regulate bone tissue regeneration through the secretion of bioactive factors and interactions with cells within the bone. Recent studies have sought to leverage the principles of neurovascular coupling in the creation of bioactive materials, yielding promising results. This article reviews nerves and vessels within the bone, the role of neural signals in bone repair, and potential mechanisms of neurovascular coupling in bone repair, expecting to provide a thorough understanding on the function of neurovascular coupling in bone repair as well as fresh perspectives on the scientific research and clinical treatment of bone repair strategies.

Key words： neurovascular coupling; bone repair; nerves within bone; tissue engineering

Cite this article

Shuhang HE , Shangchun GUO , Shicong TAO . Advances in the study of neurovascular coupling in bone repair[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024 , 44(3) : 373 -378 . DOI: 10.3969/j.issn.1674-8115.2024.03.010

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