Journal of Shanghai Jiao Tong University (Medical Science) >
Evaluation of circadian rhythms in depression by using actigraphy: a systematic review and meta-analysis
Received date: 2023-11-08
Accepted date: 2024-02-23
Online published: 2024-05-28
Supported by
MOST 2030 Brain Project(2021ZD0200600);Central Funds Guiding Local Science and Technology Development of Shanghai(YDZX20213100001003)
Objective ·To systematically review the effectiveness of actigraphy on the evaluation of circadian rhythm characteristics in patients with depression. Methods ·A systematic literature search was conducted in PubMed, Embase, Web of Science, Cochrane Library, PsycINFO, CNKI, WanFang Data, and Chinese biomedical literature database (CBM), from the inception of each database to May 5th, 2023. Case control studies that used actigraphy to evaluate circadian rhythms in patients with depression and compared them with healthy controls were collected. Literature was screened according to the inclusion and exclusion criteria, and the quality of the included literature was evaluated by using the Newcastle-Ottawa Scale. The meta-analysis was performed by using RevMan 5.4 software. Results ·A total of 9 articles were included, including 390 patients with depression and 288 healthy controls. The meta-analysis showed that the MESOR (midline statistic of rhythm) (SMD=-0.29, 95% CI -0.51 ? -0.07, P=0.009) of the circadian cosine function in patients with depression was lower than that in healthy controls; sleep onset (MD=33.06, 95% CI 14.90 ? 51.23, P=0.000) and sleep offset (MD=53.80, 95% CI 22.38 ? 85.23, P=0.000) were later in patients with depression than those in healthy controls; no statistical difference was found in the activity level of the most active 10 hours (SMD=-0.26, 95% CI -0.52 ? 0.01, P=0.060) between patients with depression and healthy controls, although there was a trend for lower activity in patients with depression; no statistical difference was found in the acrophase (MD=25.33, 95% CI -12.41 ? 63.06, P=0.190) of the circadian cosine function between patients with depression and healthy controls; no clear statistical significance of the difference was found in the amplitude (SMD=-0.14, 95% CI -0.42 ? 0.14, P=0.340) and the activity level of the least active 5 hours (SMD=0.31, 95% CI -0.10 ? 0.71, P=0.140) between patients with depression and healthy controls. Conclusion ·Actigraphy can reflect circadian rhythm disruption in patients with depression to some extent, but the limited number of included studies and inconsistencies in the study populations and methodologies have affected the quality and results of the analyses. More high-quality clinical trials are needed to provide evidence.
Key words： depression; actigraphy; circadian rhythm; meta-analysis; systematic review
Chenyin SUN , Baichuan WU , Huifeng ZHANG , Yiru FANG , Daihui PENG . Evaluation of circadian rhythms in depression by using actigraphy: a systematic review and meta-analysis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024 , 44(5) : 606 -616 . DOI: 10.3969/j.issn.1674-8115.2024.05.009
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