Journal of Shanghai Jiao Tong University (Medical Science) >
Research progress of affective touch intervention on early life stress-related anxiety disorders
Received date: 2023-05-11
Accepted date: 2024-03-26
Online published: 2024-05-28
Supported by
Innovation Program of Shanghai Municipal Education Commission(2021-01-07-00-02-E0086);Shanghai Health System Important Weak Discipline Construction Plan(2019ZB0201)
Anxiety disorders are characterized by persistent and excessive fear, anxiety and concern, accompanied by avoidance behaviors and physical symptoms such as increased heart rate, shortness of breath and muscle tension, which is one of the most prevalent psychiatric disorders. Research has shown that early life stress (ELS) can increase individual susceptibility to developing anxiety disorders during childhood and adulthood by modifying brain structure and functions. A large number of papers have reviewed the pathophysiological mechanisms of ELS-related anxiety disorders, while only a few have reviewed interventional techniques for ELS-related anxiety disorders. The phenomenon of tactile deprivation is prevalent in individuals experiencing ELS. Most current researches on affective touch and anxiety disorders suggest that affective touch is an intervention for ELS-related anxiety disorders. The review firstly introduces the phenomenon of touch deprivation in individuals experiencing ELS, discusses the effect of affective touch intervention on ELS-related anxiety disorders, and then summarizes the mechanism of affective touch in terms of neural circuits and neuroendocrinology, in order to provide reference for complementary intervention treatment of ELS-related anxiety disorders.
Key words： touch; early life stress (ELS); anxiety
Bingbing LIAO , Zhen WANG . Research progress of affective touch intervention on early life stress-related anxiety disorders[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024 , 44(5) : 647 -652 . DOI: 10.3969/j.issn.1674-8115.2024.05.014
| 1 | HUANG Y Q, WANG Y, WANG H, et al. Prevalence of mental disorders in China: a cross-sectional epidemiological study[J]. Lancet Psychiatry, 2019, 6(3): 211-224. |
| 2 | GUNNAR M, QUEVEDO K. The neurobiology of stress and development[J]. Annu Rev Psychol, 2007, 58: 145-173. |
| 3 | FERNANDES V, OSóRIO F L. Are there associations between early emotional trauma and anxiety disorders? Evidence from a systematic literature review and meta-analysis[J]. Eur Psychiatry, 2015, 30(6): 756-764. |
| 4 | TEICHER M H, SAMSON J A. Childhood maltreatment and psychopathology: a case for ecophenotypic variants as clinically and neurobiologically distinct subtypes[J]. Am J Psychiatry, 2013, 170(10): 1114-1133. |
| 5 | SZUHANY K L, SIMON N M. Anxiety disorders: a review[J]. JAMA, 2022, 328(24): 2431-2445. |
| 6 | MCGLONE F, WESSBERG J, OLAUSSON H. Discriminative and affective touch: sensing and feeling[J]. Neuron, 2014, 82(4): 737-755. |
| 7 | BYSTROVA K. Novel mechanism of human fetal growth regulation: a potential role of lanugo, vernix caseosa and a second tactile system of unmyelinated low-threshold C-afferents[J]. Med Hypotheses, 2009, 72(2): 143-146. |
| 8 | MORRIS A R, BORA S, AUSTIN N C, et al. Mental health, neurodevelopmental, and family psychosocial profiles of children born very preterm at risk of an early-onset anxiety disorder[J]. Dev Med Child Neurol, 2021, 63(8): 954-962. |
| 9 | FELDMAN R, ROSENTHAL Z, EIDELMAN A I. Maternal-preterm skin-to-skin contact enhances child physiologic organization and cognitive control across the first 10 years of life[J]. Biol Psychiatry, 2014, 75(1): 56-64. |
| 10 | ROMBAUT C, ROURA-MARTINEZ D, LEPOLARD C, et al. Brief and long maternal separation in C57Bl6J mice: behavioral consequences for the dam and the offspring[J]. Front Behav Neurosci, 2023, 17: 1269866. |
| 11 | WALKER C D, BATH K G, JOELS M, et al. Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential[J]. Stress, 2017, 20(5): 421-448. |
| 12 | SIMPSON E A, SCLAFANI V, PAUKNER A, et al. Handling newborn monkeys alters later exploratory, cognitive, and social behaviors[J]. Dev Cogn Neurosci, 2019, 35: 12-19. |
| 13 | WEI B, TAI F D, LIU X, et al. Neonatal tactile stimulation alleviates the negative effects of neonatal isolation on novel object recognition, sociability and neuroendocrine levels in male adult mandarin voles (Microtus mandarinus)[J]. Physiol Behav, 2013, 112/113: 14-22. |
| 14 | ANTONIAZZI C T, METZ V G, ROVERSI K, et al. Tactile stimulation during different developmental periods modifies hippocampal BDNF and GR, affecting memory and behavior in adult rats[J]. Hippocampus, 2017, 27(2): 210-220. |
| 15 | PICKLES A, SHARP H, HELLIER J, et al. Prenatal anxiety, maternal stroking in infancy, and symptoms of emotional and behavioral disorders at 3.5 years[J]. Eur Child Adolesc Psychiatry, 2017, 26(3): 325-334. |
| 16 | GUZZETTA A, D'ACUNTO M G, CAROTENUTO M, et al. The effects of preterm infant massage on brain electrical activity[J]. Dev Med Child Neurol, 2011, 53(Suppl 4): 46-51. |
| 17 | GONSALVES M A, BECK Q M, FUKUDA A M, et al. Mechanical affective touch therapy for anxiety disorders: effects on resting state functional connectivity[J]. Neuromodulation, 2022, 25(8): 1431-1442. |
| 18 | CARPENTER L L, KRONENBERG E F, TIRRELL E, et al. Mechanical affective touch therapy for anxiety disorders: feasibility, clinical outcomes, and electroencephalography biomarkers from an open-label trial[J]. Front Psychiatry, 2022, 13: 877574. |
| 19 | WEZE C, LEATHARD H L, GRANGE J, et al. Healing by gentle touch ameliorates stress and other symptoms in people suffering with mental health disorders or psychological stress[J]. Evid Based Complement Alternat Med, 2007, 4(1): 115-123. |
| 20 | RAPAPORT M H, SCHETTLER P, LARSON E R, et al. Acute Swedish massage monotherapy successfully remediates symptoms of generalized anxiety disorder: a proof-of-concept, randomized controlled study[J]. J Clin Psychiatry, 2016, 77(7): e883-e891. |
| 21 | HE J Y, ZHONG X, CHENG C, et al. Characteristics of white matter structural connectivity in healthy adults with childhood maltreatment[J]. Eur J Psychotraumatol, 2023, 14(1): 2179278. |
| 22 | ZHANG Y W, LIU W J, LEBOWITZ E R, et al. Abnormal asymmetry of thalamic volume moderates stress from parents and anxiety symptoms in children and adolescents with social anxiety disorder[J]. Neuropharmacology, 2020, 180: 108301. |
| 23 | SHEFFIELD J M, HUANG A S, ROGERS B P, et al. Thalamocortical anatomical connectivity in schizophrenia and psychotic bipolar disorder[J]. Schizophr Bull, 2020, 46(5): 1062-1071. |
| 24 | BENOIT L J, HOLT E S, POSANI L, et al. Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function[J]. Nat Neurosci, 2022, 25(6): 714-725. |
| 25 | MORRISON I, BJ?RNSDOTTER M, OLAUSSON H. Vicarious responses to social touch in posterior insular cortex are tuned to pleasant caressing speeds[J]. J Neurosci, 2011, 31(26): 9554-9562. |
| 26 | MAIER A, GIELING C, HEINEN-LUDWIG L, et al. Association of childhood maltreatment with interpersonal distance and social touch preferences in adulthood[J]. Am J Psychiatry, 2020, 177(1): 37-46. |
| 27 | CRAIG A D. How do you feel? Interoception: the sense of the physiological condition of the body[J]. Nat Rev Neurosci, 2002, 3(8): 655-666. |
| 28 | DAVIDOVIC M, STARCK G, OLAUSSON H. Processing of affective and emotionally neutral tactile stimuli in the insular cortex[J]. Dev Cogn Neurosci, 2019, 35: 94-103. |
| 29 | NICOLAS C, JU A, WU Y, et al. Linking emotional valence and anxiety in a mouse insula-amygdala circuit[J]. Nat Commun, 2023, 14(1): 5073. |
| 30 | NGUYEN T, ABNEY D H, SALAMANDER D, et al. Proximity and touch are associated with neural but not physiological synchrony in naturalistic mother-infant interactions[J]. NeuroImage, 2021, 244: 118599. |
| 31 | LóPEZ-SOLà M, GEUTER S, KOBAN L, et al. Brain mechanisms of social touch-induced analgesia in females[J]. Pain, 2019, 160(9): 2072-2085. |
| 32 | RICHARDS S, MYCHASIUK R, KOLB B, et al. Tactile stimulation during development alters behaviour and neuroanatomical organization of normal rats[J]. Behav Brain Res, 2012, 231(1): 86-91. |
| 33 | SHI D D, ZHANG Y D, REN Y Y, et al. Predictable maternal separation confers adult stress resilience via the medial prefrontal cortex oxytocin signaling pathway in rats[J]. Mol Psychiatry, 2021, 26(12): 7296-7307. |
| 34 | ROKITA K I, HOLLERAN L, DAUVERMANN M R, et al. Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants[J]. Soc Cogn Affect Neurosci, 2020, 15(12): 1336-1350. |
| 35 | FONZO G A, RAMSAWH H J, FLAGAN T M, et al. Early life stress and the anxious brain: evidence for a neural mechanism linking childhood emotional maltreatment to anxiety in adulthood[J]. Psychol Med, 2016, 46(5): 1037-1054. |
| 36 | KRAUS J, FRICK A, ROMAN R, et al. Soothing the emotional brain: modulation of neural activity to personal emotional stimulation by social touch[J]. Soc Cogn Affect Neurosci, 2019, 14(11): 1179-1185. |
| 37 | GORDON I, VOOS A C, BENNETT R H, et al. Brain mechanisms for processing affective touch[J]. Hum Brain Mapp, 2013, 34(4): 914-922. |
| 38 | POLLOK T M, KAISER A, KRAAIJENVANGER E J, et al. Neurostructural traces of early life adversities: a meta-analysis exploring age- and adversity-specific effects[J]. Neurosci Biobehav Rev, 2022, 135: 104589. |
| 39 | CHOI S, HACHISUKA J, BRETT M A, et al. Parallel ascending spinal pathways for affective touch and pain[J]. Nature, 2020, 587(7833): 258-263. |
| 40 | LI X, HAO S S, ZOU S M, et al. Cortex-restricted deletion of Foxp1 impairs barrel formation and induces aberrant tactile responses in a mouse model of autism[J]. Mol Autism, 2023, 14(1): 34. |
| 41 | QIN X, LIU X X, WANG Y, et al. Early life stress induces anxiety-like behavior during adulthood through dysregulation of neuronal plasticity in the basolateral amygdala[J]. Life Sci, 2021, 285: 119959. |
| 42 | TEICHER M H, ANDERSON C M, POLCARI A. Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum[J]. Proc Natl Acad Sci U S A, 2012, 109(9): E563-E572. |
| 43 | HERRINGA R J, BIRN R M, RUTTLE P L, et al. Childhood maltreatment is associated with altered fear circuitry and increased internalizing symptoms by late adolescence[J]. Proc Natl Acad Sci U S A, 2013, 110(47): 19119-19124. |
| 44 | DELPECH J C, WEI L, HAO J, et al. Early life stress perturbs the maturation of microglia in the developing hippocampus[J]. Brain Behav Immun, 2016, 57: 79-93. |
| 45 | RODRIGUES A L, ARTENI N S, ABEL C, et al. Tactile stimulation and maternal separation prevent hippocampal damage in rats submitted to neonatal hypoxia-ischemia[J]. Brain Res, 2004, 1002(1/2): 94-99. |
| 46 | WANG C, LIU H, LI K, et al. Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis[J]. Nat Commun, 2020, 11(1): 6045. |
| 47 | JURUENA M F, EROR F, CLEARE A J, et al. The role of early life stress in HPA axis and anxiety[J]. Adv Exp Med Biol, 2020, 1191: 141-153. |
| 48 | KENTNER A C, SCALIA S, SHIN J, et al. Targeted sensory enrichment interventions protect against behavioral and neuroendocrine consequences of early life stress[J]. Psychoneuroendocrinology, 2018, 98: 74-85. |
| 49 | VAN OERS H J, DE KLOET E R, WHELAN T, et al. Maternal deprivation effect on the infant′s neural stress markers is reversed by tactile stimulation and feeding but not by suppressing corticosterone[J]. J Neurosci, 1998, 18(23): 10171-10179. |
| 50 | WEAVER I C, DIORIO J, SECKL J R, et al. Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites[J]. Ann N Y Acad Sci, 2004, 1024: 182-212. |
| 51 | LABUSCHAGNE I, PHAN K L, WOOD A, et al. Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder[J]. Neuropsychopharmacology, 2010, 35(12): 2403-2413. |
| 52 | TANG Y, BENUSIGLIO D, LEFEVRE A, et al. Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons[J]. Nat Neurosci, 2020, 23(9): 1125-1137. |
| 53 | YU H, MIAO W Y, JI E, et al. Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions[J]. Neuron, 2022, 110(6): 1051-1067.e7. |
| 54 | GRINEVICH V, NEUMANN I D. Brain oxytocin: how puzzle stones from animal studies translate into psychiatry[J]. Mol Psychiatry, 2021, 26(1): 265-279. |
| 55 | NAKAMOTO K, TANIGUCHI A, TOKUYAMA S. Changes in opioid receptors, opioid peptides and morphine antinociception in mice subjected to early life stress[J]. Eur J Pharmacol, 2020, 881: 173173. |
| 56 | HOROVITZ O, ARDI Z, ASHKENAZI S K, et al. Network neuromodulation of opioid and GABAergic receptors following a combination of “juvenile” and “adult stress” in rats[J]. Int J Mol Sci, 2020, 21(15): 5422. |
| 57 | NAKAMOTO K, TOKUYAMA S. Stress-induced changes in the endogenous opioid system cause dysfunction of pain and emotion regulation[J]. Int J Mol Sci, 2023, 24(14): 11713. |
| 58 | KEVERNE E B, MARTENSZ N D, TUITE B. Beta-endorphin concentrations in cerebrospinal fluid of monkeys are influenced by grooming relationships[J]. Psychoneuroendocrinology, 1989, 14(1/2): 155-161. |
| 59 | MORHENN V, BEAVIN L E, ZAK P J. Massage increases oxytocin and reduces adrenocorticotropin hormone in humans[J]. Altern Ther Health Med, 2012, 18(6): 11-18. |
| 60 | NUMMENMAA L, TUOMINEN L, DUNBAR R, et al. Social touch modulates endogenous μ-opioid system activity in humans[J]. Neuroimage, 2016, 138: 242-247. |
/
| 〈 |
|
〉 |