Journal of Shanghai Jiao Tong University (Medical Science) >

2024 , Vol. 44 >Issue 7: 814 - 821

DOI: https://doi.org/10.3969/j.issn.1674-8115.2024.07.002

Topics on advances in translational medicine frontiers

Progress in translational research on immunotherapy for osteosarcoma

  • Fei HU ,
  • Xiaohan CAI ,
  • Rui CHENG ,
  • Shiyu JI ,
  • Jiaxin MIAO ,
  • Yan ZHU ,
  • Guangjian FAN
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  • 1.Department of Bone and Joint Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China
    2.Central Laboratory, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
    3.Department of Ultrasound, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
    4.Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
    5.Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
    6.State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China
    7.Precision Research Center for Difficult Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China
FAN Guangjian, E-mail: gjfan@shsmu.edu.cn.

Received date: 2023-12-28

  Accepted date: 2024-05-22

  Online published: 2024-07-28

Supported by

National Natural Science Foundation of China(32270749);Taishan Scholar Project of Shandong Province (Young Expert Program)(tsqn202306197)

Fold

Abstract

Osteosarcoma is a common primary malignant bone tumor in adolescents and children, characterized by a high recurrence rate and metastasis, making its treatment extremely challenging. Traditional treatment modalities, including surgery, radiation therapy, and chemotherapy, can alleviate symptoms to some extent, but improving long-term survival rates remains a pressing issue. With the continuous development of immunotherapy, breakthroughs have been made in the research of tumor immune microenvironment and the application of immunotherapy in recent years, providing new perspectives and strategies for osteosarcoma treatment. Currently, immunotherapy strategies include tumor vaccines, targeted cytokines, immune checkpoint inhibition, adoptive cell therapy, combination therapy, etc., significantly enhancing patient immune responses from the aspects of boosting immunity, overcoming immune tolerance, and preventing immune evasion, thereby effectively improving the patients′ survival rates and prognosis. This review aims to systematically introduce the immune microenvironment of osteosarcoma and discuss the latest advances in immunotherapy in clinical translational research of osteosarcoma. By deeply understanding the immune characteristics of osteosarcoma and corresponding treatment methods, it is hopeful to provide more effective strategies for personalized treatment, contributing to the improvement of the patients′ survival rates and prognosis.

Key words： osteosarcoma; tumor immune microenvironment (TIME); immunotherapy; clinical translation

Cite this article

Fei HU , Xiaohan CAI , Rui CHENG , Shiyu JI , Jiaxin MIAO , Yan ZHU , Guangjian FAN . Progress in translational research on immunotherapy for osteosarcoma[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024 , 44(7) : 814 -821 . DOI: 10.3969/j.issn.1674-8115.2024.07.002

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