Journal of Shanghai Jiao Tong University (Medical Science) >
Progress in cumulative risk assessment of human health from combined exposure to environmental pollutants
Received date: 2023-12-15
Accepted date: 2024-03-22
Online published: 2024-08-27
Supported by
National Natural Science Foundation of China(41991314);Shanghai Municipal Health Commission Collaborative Innovation Cluster Project(20YF1423400)
The combined exposure to environmental pollutants can result in unanticipated adverse effects on human health, and how to compare and assess these effects has always been a matter of great concern for the international community. Currently, several prevalent methods for assessing combined exposure risks in the field of human health risk assessment primarily encompass the hazard index (HI) method, the point of departure index (PODI) method, the margin of exposure (MOE) method, and the relative potency factor (RPF) method. The review summarizes the application of these methods to the cumulative risk assessment of combined exposure to the same class of chemicals with the same toxic mechanism, primarily focusing on pesticides such as organophosphorus pesticides, pyrethroids, carbamates, and neonicotinoids, as well as typical compounds intimately related to human production and life, including organophosphorus flame retardants, per- and poly-fluoroalkyl substances, and bisphenols. Furthermore, progress in the application of physiologically based pharmacokinetics models to human health risk assessment has been introduced, which might provide more options for risk assessment of combined exposure to multiple chemicals, and help to provide insights for further exploration and establishment of more systematic and scientific approaches to human health risk assessment.
Xiaomeng CHENG , Yan ZHANG , Yu GAO , Ying TIAN . Progress in cumulative risk assessment of human health from combined exposure to environmental pollutants[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024 , 44(8) : 1037 -1043 . DOI: 10.3969/j.issn.1674-8115.2024.08.013
| 1 | ZHENG G M, SCHREDER E, DEMPSEY J C, et al. Per- and polyfluoroalkyl substances (PFAS) in breast milk: concerning trends for current-use PFAS[J]. Environ Sci Technol, 2021, 55(11): 7510-7520. |
| 2 | XU Z K, DU B, WANG H L, et al. Perfluoroalkyl substances in umbilical cord blood and blood pressure in offspring: a prospective cohort study[J]. Environ Health, 2023, 22(1): 72. |
| 3 | LIU J J, CUI X X, TAN Y W, et al. Per- and perfluoroalkyl substances alternatives, mixtures and liver function in adults: a community-based population study in China[J]. Environ Int, 2022, 163: 107179. |
| 4 | INDIA ALDANA S, COLICINO E, CANTORAL PRECIADO A, et al. Longitudinal associations between early-life fluoride exposures and cardiometabolic outcomes in school-aged children[J]. Environ Int, 2024, 183: 108375. |
| 5 | WILBUR S B, HANSEN H, POHL H, et al. Using the ATSDR guidance manual for the assessment of joint toxic action of chemical mixtures[J]. Environ Toxicol Pharmacol, 2004, 18(3): 223-230. |
| 6 | ZHANG Q, MA C, LV D Z, et al. Multiresidue analysis and dietary intake risk assessment of 29 pesticides in banana from five provinces of southern China[J]. J Food Compos Anal, 2024, 125: 105819. |
| 7 | LIU Y H, BEI K, ZHENG W R, et al. Pesticide residues risk assessment and quality evaluation of four characteristic fruits in Zhejiang Province, China[J]. Front Environ Sci, 2023, 11: 1124094. |
| 8 | WU M N, ZHANG W H, MIAO J J, et al. Pyrethroids contamination and health risk assessment in seafood collected from the coast of Shandong, China[J]. Mar Pollut Bull, 2023, 186: 114442. |
| 9 | FILIPPI I, BRAVO N, GRIMALT J O, et al. Pilot study of exposure of the male population to organophosphate and pyrethroid pesticides in a region of high agricultural activity (Córdoba, Argentina)[J]. Environ Sci Pollut Res Int, 2021, 28(38): 53908-53916. |
| 10 | FERNáNDEZ S F, PARDO O, ADAM-CERVERA I, et al. Biomonitoring of non-persistent pesticides in urine from lactating mothers: exposure and risk assessment[J]. Sci Total Environ, 2020, 699: 134385. |
| 11 | F FERNáNDEZ S, PARDO O, CORPAS-BURGOS F, et al. Exposure and cumulative risk assessment to non-persistent pesticides in Spanish children using biomonitoring[J]. Sci Total Environ, 2020, 746: 140983. |
| 12 | WANG H X, YANG D J, FANG H J, et al. Predictors, sources, and health risk of exposure to neonicotinoids in Chinese school children: a biomonitoring-based study[J]. Environ Int, 2020, 143: 105918. |
| 13 | ZHOU W L, YUE M, LIU Q, et al. Measuring urinary concentrations of neonicotinoid insecticides by modified solid-phase extraction-ultrahigh performance liquid chromatography-tandem mass spectrometry: application to human exposure and risk assessment[J]. Chemosphere, 2021, 273: 129714. |
| 14 | FAURE S, NOISEL N, WERRY K, et al. Evaluation of human biomonitoring data in a health risk based context: an updated analysis of population level data from the Canadian Health Measures Survey[J]. Int J Hyg Environ Health, 2020, 223(1): 267-280. |
| 15 | SUWANNARIN N, NISHIHAMA Y, ISOBE T, et al. Urinary concentrations of environmental phenol among pregnant women in the Japan Environment and Children's Study[J]. Environ Int, 2024, 183: 108373. |
| 16 | BORG D, LUND B O, LINDQUIST N G, et al. Cumulative health risk assessment of 17 perfluoroalkylated and polyfluoroalkylated substances (PFASs) in the Swedish population[J]. Environ Int, 2013, 59: 112-123. |
| 17 | AO J J, YUAN T, XIA H, et al. Characteristic and human exposure risk assessment of per- and polyfluoroalkyl substances: a study based on indoor dust and drinking water in China[J]. Environ Pollut, 2019, 254(Pt A): 112873. |
| 18 | LI J F, WU C S, ZHAO H Z, et al. Exposure assessment of bisphenols in Chinese women during pregnancy: a longitudinal study[J]. Environ Sci Technol, 2019, 53(13): 7812-7820. |
| 19 | ZHANG B, LU S Y, HUANG M Z, et al. Urinary metabolites of organophosphate flame retardants in 0?5-year-old children: potential exposure risk for inpatients and home-stay infants[J]. Environ Pollut, 2018, 243(Pt A): 318-325. |
| 20 | CHEN Y, JIANG L, LU S Y, et al. Organophosphate ester and phthalate ester metabolites in urine from primiparas in Shenzhen, China: implications for health risks[J]. Environ Pollut, 2019, 247: 944-952. |
| 21 | 杨桂玲, 陈晨, 王强, 等. 农药多残留联合暴露风险评估研究进展[J]. 农药学学报, 2015, 17(2): 119-127. |
| 21 | YANG G L, CHEN C, WANG Q, et al. Risk assessment for combined exposure of multiresidue of pesticides[J]. Chinese Journal of Pesticide Science, 2015, 17(2): 119-127. |
| 22 | WONG H L, GARTHWAITE D G, RAMWELL C T, et al. Assessment of occupational exposure to pesticide mixtures with endocrine-disrupting activity[J]. Environ Sci Pollut Res Int, 2019, 26(2): 1642-1653. |
| 23 | BARLOW S, RENWICK A G, KLEINER J, et al. Risk assessment of substances that are both genotoxic and carcinogenic: report of an International Conference organized by EFSA and WHO with support of ILSI Europe[J]. Food Chem Toxicol, 2006, 44(10): 1636-1650. |
| 24 | EFSA Scientific Committee, MORE S J, BAMPIDIS V, et al. Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals[J]. EFSA J, 2019, 17(3): e05634. |
| 25 | EFSA Scientific Committee. Statement on the applicability of the Margin of Exposure approach for the safety assessment of impurities which are both genotoxic and carcinogenic in substances added to food/feed[J]. EFSA J, 2012, 10(3): 2578. |
| 26 | ?ULC L, JANO? T, FIGUEIREDO D, et al. Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: urinary biomarker levels and associated health risks[J]. Environ Res, 2022, 214(Pt 3): 114002. |
| 27 | REN J X, TAO C J, ZHANG L Y, et al. Potential exposure to clothianidin and risk assessment of manual users of treated soil[J]. Pest Manag Sci, 2017, 73(9): 1798-1803. |
| 28 | CAO L D, ZHANG H J, LI F M, et al. Potential dermal and inhalation exposure to imidacloprid and risk assessment among applicators during treatment in cotton field in China[J]. Sci Total Environ, 2018, 624: 1195-1201. |
| 29 | 韩瑞旗, 刘小芳, 梁正雅, 等. 农药制剂加工从业人员农药暴露风险评估[J]. 世界农药, 2023, 45(8): 1-6, 60. |
| 29 | HAN R Q, LIU X F, LIANG Z Y, et al. Risk assessment of pesticide exposure to seed coating formulation workers[J]. World Pesticides, 2023, 45(8): 1-6, 60. |
| 30 | SILVA A V, RINGBLOM J, LINDH C, et al. A probabilistic approach to evaluate the risk of decreased total triiodothyronine hormone levels following chronic exposure to PFOS and PFHxS via contaminated drinking water[J]. Environ Health Perspect, 2020, 128(7): 76001. |
| 31 | YOU S H, YU C C. Health risk exposure assessment of migration of perfluorooctane sulfonate and perfluorooctanoic acid from paper and cardboard in contact with food under temperature variations[J]. Foods, 2023, 12(9): 1764. |
| 32 | BUTENHOFF J L, GAYLOR D W, MOORE J A, et al. Characterization of risk for general population exposure to perfluorooctanoate[J]. Regul Toxicol Pharmacol, 2004, 39(3): 363-380. |
| 33 | DEL GOBBO L, TITTLEMIER S, DIAMOND M, et al. Cooking decreases observed perfluorinated compound concentrations in fish[J]. J Agric Food Chem, 2008, 56(16): 7551-7559. |
| 34 | United States Environmental Protection Agency. Guidance for health risk from exposure to chemical mixtures[S/OL]. (1986-09-24)[2023-11-13]. https://www.epa.gov/sites/default/files/2014-11/documents/chem_mix_1986.pdf. |
| 35 | CUI K, WU X H, WEI D M, et al. Health risks to dietary neonicotinoids are low for Chinese residents based on an analysis of 13 daily-consumed foods[J]. Environ Int, 2021, 149: 106385. |
| 36 | WANG L L, MA C C, WEI D D, et al. Health risks of neonicotinoids chronic exposure and its association with glucose metabolism: a case-control study in rural China[J]. Environ Pollut, 2023, 334: 122213. |
| 37 | MAHAI G G, WAN Y J, XIA W, et al. A nationwide study of occurrence and exposure assessment of neonicotinoid insecticides and their metabolites in drinking water of China[J]. Water Res, 2021, 189: 116630. |
| 38 | WEI X, PAN Y N, TANG Z X, et al. Neonicotinoids residues in cow milk and health risks to the Chinese general population[J]. J Hazard Mater, 2023, 452: 131296. |
| 39 | LI S H, REN J, LI L F, et al. Temporal variation analysis and risk assessment of neonicotinoid residues from tea in China[J]. Environ Pollut, 2020, 266(Pt 2): 115119. |
| 40 | MAHAI G G, WAN Y J, XIA W, et al. Exposure assessment of neonicotinoid insecticides and their metabolites in Chinese women during pregnancy: a longitudinal study[J]. Sci Total Environ, 2022, 818: 151806. |
| 41 | ZHANG Q, MO X J, LOU J L, et al. Occurrence, distribution and potential risk to infants of neonicotinoids in breast milk: a case study in Hangzhou, China[J]. Sci Total Environ, 2023, 878: 163044. |
| 42 | OYA N, ITO Y, EBARA T, et al. Cumulative exposure assessment of neonicotinoids and an investigation into their intake-related factors in young children in Japan[J]. Sci Total Environ, 2021, 750: 141630. |
| 43 | ZHANG Q, YING Z T, TANG T, et al. Residual characteristics and potential integrated risk assessment of synthetic pyrethroids in leafy vegetables from Zhejiang in China: based on a 3-year investigation[J]. Food Chem, 2021, 365: 130389. |
| 44 | LI Q Q, LI B, CHEN D W, et al. Dietary exposure risk assessment of pyrethroids in fruits and vegetables: a national scale investigation[J]. Environ Sci Pollut Res Int, 2023, 30(35): 84620-84630. |
| 45 | BIL W, EHRLICH V, CHEN G C, et al. Internal relative potency factors based on immunotoxicity for the risk assessment of mixtures of per- and polyfluoroalkyl substances (PFAS) in human biomonitoring[J]. Environ Int, 2023, 171: 107727. |
| 46 | BIL W, ZEILMAKER M J, BOKKERS B G H. Internal relative potency factors for the risk assessment of mixtures of per- and polyfluoroalkyl substances (PFAS) in human biomonitoring[J]. Environ Health Perspect, 2022, 130(7): 77005. |
| 47 | BIL W, ZEILMAKER M, FRAGKI S, et al. Risk assessment of per- and polyfluoroalkyl substance mixtures: a relative potency factor approach[J]. Environ Toxicol Chem, 2021, 40(3): 859-870. |
| 48 | COHEN HUBAL E A, WETMORE B A, WAMBAUGH J F, et al. Advancing internal exposure and physiologically-based toxicokinetic modeling for 21st-century risk assessments[J]. J Expo Sci Environ Epidemiol, 2019, 29(1): 11-20. |
| 49 | HUS?Y T, CASPERSEN I H, THéPAUT E, et al. Comparison of aggregated exposure to perfluorooctanoic acid (PFOA) from diet and personal care products with concentrations in blood using a PBPK model: results from the Norwegian biomonitoring study in EuroMix[J]. Environ Res, 2023, 239(Pt 2): 117341. |
| 50 | COOPER A B, AGGARWAL M, BARTELS M J, et al. PBTK model for assessment of operator exposure to haloxyfop using human biomonitoring and toxicokinetic data[J]. Regul Toxicol Pharmacol, 2019, 102: 1-12. |
| 51 | KARRER C, DE BOER W, DELMAAR C, et al. Linking probabilistic exposure and pharmacokinetic modeling to assess the cumulative risk from the bisphenols BPA, BPS, BPF, and BPAF for Europeans[J]. Environ Sci Technol, 2019, 53(15): 9181-9191. |
| 52 | HU M, ZHANG Z C, ZHANG Y N, et al. Development of human dermal PBPK models for the bisphenols BPA, BPS, BPF, and BPAF with parallel-layered skin compartment: basing on dermal administration studies in humans[J]. Sci Total Environ, 2023, 868: 161639. |
| 53 | BERNSTEIN A S, KAPRAUN D F, SCHLOSSER P M. A model template approach for rapid evaluation and application of physiologically based pharmacokinetic models for use in human health risk assessments: a case study on per- and polyfluoroalkyl substances[J]. Toxicol Sci, 2021, 182(2): 215-228. |
/
| 〈 |
|
〉 |