Journal of Shanghai Jiao Tong University (Medical Science) >
Research progress on immune microenvironment and immunotherapy of endometrial cancer
Received date: 2025-07-31
Accepted date: 2026-03-02
Online published: 2026-05-28
Supported by
Natural Science Foundation of Shanghai(22ZR1447300)
Endometrial carcinoma (EC) is a common malignant tumor that poses a severe threat to women's health. Driven by an aging population and the high prevalence of metabolic diseases, the incidence of EC continues to rise. For advanced or recurrent EC, traditional therapeutic regimens exhibit limited efficacy and are prone to drug resistance, leading to a generally poor overall prognosis. To overcome this clinical bottleneck, immunotherapeutic strategies, characterized by high targeting specificity and durable efficacy, have opened up a novel direction for clinical treatment. This review systematically summarizes the cellular composition and molecular subtyping characteristics of the EC immune microenvironment, and elaborates on the research progress of immune checkpoint inhibitors (ICIs) in monotherapy and combination regimens. Furthermore, it provides an in-depth analysis of current challenges, including efficacy heterogeneity and drug resistance, to provide a reference for the clinical practice and theoretical research of precision immunotherapy for EC.
Chen Yuhan , Ai Zhihong . Research progress on immune microenvironment and immunotherapy of endometrial cancer[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026 , 46(5) : 656 -664 . DOI: 10.3969/j.issn.1674-8115.2026.05.012
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