Influence of parecoxib sodium for postoperative analgesia on hepato-renal function and drug consumption of patient-controlled epidural analgesia
Online published: 2010-11-29
Objective To observe the influence of postoperative application of parecoxib sodium combined with patient-controlled epidural analgesia (PCEA) on hepato-renal function and drug consumption of PCEA. Methods Sixty women undergoing epidural anesthesia were randomly divided into 2 groups (n=30). Patients in parecoxib sodium+PCEA group were intravenously injected with 40 mg parecoxib sodium after abdominal closure, and were then managed with PCEA pump (0.005% morphine+0.24% ropivacaine mesylate), while patients in PCEA group were only managed with PCEA pump (0.005% morphine+0.24% ropivacaine mesylate) after abdominal closure. Parameters of hepato-renal function were measured 24 h after operation. Visual analogue scale (VAS) scores were obtained 4, 8, 12 and 24 h after operation, and palping times of PCEA and drug consumption of PCEA were recorded meanwhile. Results There was no significant change in parameters of hepato-renal function after operation in both groups(P>0.05). VAS scores, palping times of PCEA and drug consumption of PCEA 4, 8, 12 and 24 h after operation in parecoxib sodium+PCEA group were significantly lower than those in PCEA group(P<0.05 or P<0.01). There was no additional analgesic medication for both groups. Conclusion Parecoxib sodium for postoperative analgesia has no significant influence on hepato-renal function, while it can obviously enhance the analgesic effect and decrease the drug consumption of PCEA.
WANG Chun-yu, WANG Shi-lei, ZHANG Pi-xing . Influence of parecoxib sodium for postoperative analgesia on hepato-renal function and drug consumption of patient-controlled epidural analgesia[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2010 , 30(11) : 1405 . DOI: 10.3969/j.issn.1674-8115.2010.11.021
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