Laser has been widely used in medical area. Low level laser therapy can promote cell growth through biostimulation. Laser may initiate photochemical reaction that causes light-induced polymerization, which can assist in various tissue wound closures. In addition, laser can be utilized to treat wound infection efficiently by photooxidation reaction. An effective improvement of scar reduction can be produced by fractional laser treatment. Laser may play more important roles in tissue wound repair in the future.