Objective To investigate the efficacy of different antibiotics for the treatment of pan-drug-resistant Acinetobacter baumannii (PDR-AB) infection. Methods The clinical characteristics, application of antibiotics and outcomes of 20 patients with severe PDR-AB infection were retrospectively analysed. Results Seven patients were treated with highdose cefoperazone-sulbactam monotherapy (9 to 12 g/d), and the other 13 were managed with cefoperazonesulbactam combined with levofloxacin or minocycline, with the mean course of treatment of (13.3±5.3）d, clinical effective rate of 50.0% and bacteria clearance rate of 35.0%. Five of the 10 patients unresponsive to the initial therapy were administrated with colistin sulfate, with the mean course of treatment of (16.8±5.0）d, clinical effective rate of 80.0% and bacteria clearance rate of 60.0%. For all the 20 patients, the total clinical effective rate was 70.0%, the bacteria clearance rate was 50.0%, and the mortality was 30.0%. Conclusion For the management of PDR-AB infection, highdose cefoperazone-sulbactam with or without minocycline may be effective, and colistin is also viable and safe with a favorable clinical outcome.