As a newly discovered RNA interference method, long noncoding RNAs (lncRNA) play an important role in the development and progression of carcinomas, just as other epigenetic mechanisms including DNA methylation, histone modifications and chromatin remodeling. Recent researches have highlighted that lncRNA can interact with other epigenetic mechanisms. lncRNA can regulate DNA methylation, histone modifications, chromatin remodeling and other RNA interference through many ways, and the expression and role of lncRNA can be regulated by DNA methylation and chromatin remodeling. The complex relationship affects the development and progression of carcinomas.