Congenital heart disease (CHD) is a category of severe illness threatening children's health. However, favorable outcome can be achieved with proper management. Unfortunately, CHD remains a health challenge for children and families in many developing countries due to insufficient medical resource. During the past 30 years, the management of pediatric CHD has been greatly improved in China. Specifically, Project HOPE has played an important role in facilitating the collaboration between Shanghai Children's Medical Center and many world'leading pediatric health care institutions, which has provided valuable opportunity to enable the growth of Shanghai Children's Medical Center into a state-of-theart hospital.