Monographic report (Bipolar disorder)

Association of 5HTTLPR gene polymorphisms with bipolar disorder and affective temperaments

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  • 1.Department of Mood Disorder, 2.Department of Genetics, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China

Online published: 2011-11-29

Supported by

National Natural Science Foundation of China, 30270494;National High Technology Research and Development Program of China, “863” Program, 2006AA02Z430;National Key Technology Research and Development Program of China in “Tenth-Five Year Plan”, 2004BA720A21-02;Shanghai Municipal Health Bureau Foundation, 08GWQ075, 2007Y14;Shanghai Jiaotong University School of Medicine Foundation, 2008-6

Abstract

Objective To explore the association of serotonin transporter gene-linked polymorphic region (5-HTTLPR) gene polymorphisms with bipolar disorder and affective temperaments. Methods Case-control design was adopted, and 305 patients with bipolar disorder and 272 normal controls were enrolled. Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A) was employed to assess the affective temperaments. Chi-square test, T test, nonparametric test and ANOVA were used to explore the association of 5-HTTLPR gene polymorphisms with bipolar disorder and affective temperaments. Results 5-HTTLPR L/S polymorphisms were associated with bipolar disorder in females (genotype, χ2=6.769, P=0.034;allele, χ2=6.028, P=0.014), S allele of 5-HTTLPR L/S polymorphisms was associated with anxious temperament of patients with bipolar disorder (t=8.248,P=0.005), and LA allele of 5-HTTLPR rs25531 A/G polymorphisms was associated with hyperthymic temperament of patients with bipolar disorder (Z=-2.205,P=0.027). Conclusion 5-HTTLPR gene polymorphisms are associated with the prevalence of bipolar disorder in females, which can also regulate the affective temperaments of patients with bipolar disorder in some degree.

Cite this article

YUAN Cheng-mei, YU Shun-ying, LI Ze-zhi, et al . Association of 5HTTLPR gene polymorphisms with bipolar disorder and affective temperaments[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2011 , 31(11) : 1518 . DOI: 10.3969/j.issn.1674-8115.2011.11.003

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