Original article (Basic research)

Effects of dietary resistant starch on glucose metabolism in offsprings of diabetic rats

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  • 1.Department of Clinical Nutrition, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China;2.Department of Endocrinology and Metabolism, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China;3.Laboratory of Endocrinology and Metabolism, Veterans Affairs Medical Center, Washington DC 20422, USA

Online published: 2012-01-04

Abstract

Objective To investigate the effects of dietary resistant starch on glucose metabolism in offsprings of diabetic rats. Methods Twenty female Goto-Kakizaki (GK) rats with type 2 diabetes aged 6 weeks were randomized into resistant starch diet group (GK-RS group, n=10) and energy control diet group (GK-EC group, n=10), and another 10 age-matched female Wistar rats fed with energy control diet were served as blank control group (Wistar-EC group). Ten male offsprings were randomly selected in each group, and were raised till 8 weeks old on regular chow diet. Body weight and volume of food intake were recorded three time a week, pancreatic relative β cell density was measured by immunohistochemistry, fasting serum insulin concentration was detected by ELISA, concentrations of fasting blood glucose and 2 h postprandial blood glucose were determined by oral glucose tolerance test, and insulin sensitivity was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Results Compared with GK-EC group, the concentration of fasting blood glucose significantly decreased (P<0.05), pancreatic insulin content significantly increased (P<0.05), and pancreatic relative β cell density tended to increase in GK-RS group (P=0.07). There was no significant difference in body weight, volume of food intake, HOMA-IR and concentrations of 2 h postprandial blood glucose and fasting serum insulin between GK-EC group and GK-RS group (P>0.05). Conclusion Dietary resistant starch has potential in improving glucose metabolism disorder in offsprings born to diabetic dams.

Cite this article

SHEN Li, YIN Jun, ZHOU Jun . Effects of dietary resistant starch on glucose metabolism in offsprings of diabetic rats[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2011 , 31(12) : 1707 . DOI: 10.3969/j.issn.1674-8115.2011.12.010

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