Review

Research progress of chemokine receptor-5 related cardiac allograft vasculopathy

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  • Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

Online published: 2012-01-04

Supported by

Shanghai Science and Technology Committee Foundation, 9411964400;Shanghai Municipal Health Bureau Foundation, 2008108

Abstract

Cardiac allograft vasculopathy (CAV) continues to limit the long-term success of cardiac transplantation and has become a leading cause for death and retransplantation in patients who survive beyond the first year after heart transplantation. At present, it is considered that both immunologic and nonimmunologic risk factors contribute to the development of CAV by causing endothelial dysfunction and injury, eventually leading to progressive intimal thicking and ischemic failure of the cardiac allograft. Chemokines and their receptors may participate in regulating the local immune response of the graft. Among them, chemokine receptor-5 (CCR5) may play an important role in the pathogenesis of CAV, but the mechanism is unclear. So far, the therapy for CAV has been relatively limited, but there have been some new findings with the research progress of CCR5, which provides a new direction for the treatment and prevention of CAV.

Cite this article

JIANG Zhao-lei, HE Yi, MEI Ju . Research progress of chemokine receptor-5 related cardiac allograft vasculopathy[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2011 , 31(12) : 1775 . DOI: 10.3969/j.issn.1674-8115.2011.12.026

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