Research progress of antiangiogenic activity of tumstatin
Online published: 2012-02-28
Supported by
Shanghai Science and Technology Committee Foundation, 11BA1409700;Shanghai Jiaotong University School of Medicine Foundation, 11XJ21056;Shanghai Key Laboratory for Ocular Fundus Diseases Foundation, 07Z22911
Tumstatin is a bioactivator which can effectively suppress tumor growth by inhibiting both angiogenesis of tumor vessels and proliferation of tumor cells. Tumstatin has great ability to cause tumor stasis. The bioactivity and mechanisms of tumstatin have been gradually revealed. The antiangiogenic activity and mechanisms of tumstatin are reviewed in this paper, and the prospect of application of tumstatin in ophthalmology is explored.
Key words: tumstatin; type Ⅳ collagen alpha3 chain; angiogenesis
MA Ying-yan, ZOU Hai-dong . Research progress of antiangiogenic activity of tumstatin[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2012 , 32(2) : 214 . DOI: 10.3969/j.issn.1674-8115.2012.02.020
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