Kawasaki disease (KD) is an acute vasculitis syndrome, which mainly affects medium and small arteries, with a particular predilection for coronary arteries. Patients with KD having serious coronary artery lesion may result in myocardial infarction and sudden death. There is no specific method in diagnosis of KD with coronary artery lesion. Cardiovascular imaging techniques such as echocardiography, myocardial contrast echocardiography, myocardial perfusion scan, stress echocardiography, magnetic resonance imaging, CT, coronary angiography and intravascular ultrasound imaging can evaluate coronary abnormalities. The research progress of cardiovascular imaging in diagnosis of KD with coronary artery lesion is reviewed in this paper.