Preeclampsia (PE) is a pregnancy-specific multi-system dysfunction disease, which is one of the main causes of maternal and infant mortality. The pathogenesis of PE is not clear, inflammation, coagulation function changes, platelet activation and endothelial damage may have significant impact on the pathological process of PE, and studies have confirmed that microparticles (MP) play an important role in the above process. The research progress of generation and characteristics of MP, the changes of contents of MP in systemic circulation during pregnancy, and the pathogenesis of MP in PE is reviewed, and the prospect of MP in the diagnosis and treatment of PE is explored in this paper.