Journal of Shanghai Jiao Tong University (Medical Science) >

2012 , Vol. 32 >Issue 8: 1010

DOI: https://doi.org/10.3969/j.issn.1674-8115.2012.08.011

Monographic report (Infertility and assisted reproductive technology)

Research progress of effects of PDE5 inhibitors on sperm motility and fertilizing capacity

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  • Department of Urology, Shanghai Human Sperm Bank, Sperm Development and Genetics Laboratory, Shanghai Institute of Andrology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China

Online published: 2012-08-29

Supported by

Shanghai Science and Technology Committee Foundation, 10JC1409900

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Abstract

Phosphodiesterase-5 (PDE5) inhibitors are commonly used in the treatment of penile erectile dysfunction (ED). Recent studies have revealed that PDE5 inhibitors have impact on sperm motility and fertilizing capacity, and can significantly improve sperm motility in the appropriate concentration. The effects of PDE5 inhibitors on sperm motility and fertilizing capacity are reviewed in this paper.

Key words： phosphodiesterase-5 inhibitor; spermatozoa; motility; fertilization

Cite this article

LU Ke-min, LU Hui, LI Zheng . Research progress of effects of PDE5 inhibitors on sperm motility and fertilizing capacity[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2012 , 32(8) : 1010 . DOI: 10.3969/j.issn.1674-8115.2012.08.011

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