Original article (Clinical research)

Application of 18F-FDG PET/CT in patients with negative findings in serum Tg measurement and 131I-whole body scan after ablation of remaining thyroid tissues for differentiated thyroid carcinoma

Expand
  • Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

Online published: 2012-08-29

Supported by

Shanghai Leading Academic Discipline Project, S30203

Abstract

Objective To investigate the application of 18F-FDG PET/CT in detection of tumor  recurrence and metastasis among patients with negative findings in serum thyroglobulin (Tg) measurement and 131I-whole body scan (131I-WBS) after total thyroidectomy and 131I ablation of the remaining thyroid tissues for differentiated thyroid carcinoma (DTC). Methods Forty-one patients with DTC underwent total thyroidectomy and 131I ablation of the remaining thyroid tissues, and were followed up with serum Tg measurement, 131I-WBS, neck ultrasound, chest CT and whole body 18F-FDG PET/CT. Results All these 41 patients had negative findings in serum Tg measurement and 131I-WBS, while abnormal lesions were detected by neck ultrasound or chest CT. Twenty-three patients had positive findings in 18F-FDG PET/CT, 3 of whom were confirmed as thyroid carcinoma metastases by pathological examinations. There was no significant difference between the size of 18F-FDG PET/CT positive lesions and that of 18F-FDG PET/CT negative lesions. Conclusion 18F-FDG PET/CT may demonstrate suspicious positive lesions in patients with negative findings in serum Tg measurement and 131I-WBS after total thyroidectomy and 131I ablation of the remaining thyroid tissues for DTC, which may help in the detection of tumor recurrence and metastasis.

Cite this article

CHENG Wei-wei, WANG Hui, FENG Fang, et al . Application of 18F-FDG PET/CT in patients with negative findings in serum Tg measurement and 131I-whole body scan after ablation of remaining thyroid tissues for differentiated thyroid carcinoma[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2012 , 32(8) : 1068 . DOI: 10.3969/j.issn.1674-8115.2012.08.022

Outlines

/