Objective To investigate the therapeutic effect of minimally-invasive drainage on epidural hematoma straddling transverse sinus. Methods Fifty-eight patients with traumatic epidural hematoma straddling transverse sinus and preoperative Glasgow Coma Score (GCS) 8 to 12 points were managed with minimally-invasive drainage under CT location, and 50 000 to 60 000 IU of urokinase was used for irrigation and drainage. CT scanning was performed 1 h, 3 d and 7 d after operation, volumes of hematoma were calculated, and Glasgow Outcome Score (GOS) was evaluated 3 months after operation. Results The volumes of hematoma 1 h and 3 d after operation were (20±5) mL and (15±2) mL respectively, and were significantly lower than that before operation [(45±15) mL](P＜0.05). The hematoma was totally removed 3 to 5 d after operation. GCS was (12±1) points 5 d after operation, which was significantly higher than that before operation [(8±4) points](P＜0.05). Three months after operation, good recovery (GOS 5 points) was achieved in 45 patients (78%), and moderate disability (GOS 4 points) was found in 9 patients (16%). Conclusion Minimally-invasive drainage is effective in the treatment of traumatic epidural hematoma straddling transverse sinus with GCS≥8 points.